269 medications are known to interact with omeprazole. Includes: drug, food, pregnancy, breastfeeding and therapeutic duplication warnings. Learn about omeprazole drug interactions backed by FDA labeling. Understand which medications are contraindicated and what to discuss with your pharmacist. See the list of drugs that interact with Omeprazole. Includes information on severity of interaction and the level of evidence for it. Omeprazole inhibits CYP2C19 and may affect the metabolism of drugs processed by this enzyme. It also raises gastric pH, which can alter the absorption of pH-dependent medications. Does omeprazole interact with my other drugs? Enter medications to view a detailed interaction report using our Drug Interaction Checker. Omeprazole can interact with blood thinners, HIV drugs, antifungals, and more. Here’s what to know before combining it with other medications. Omeprazole (Prilosec) is a medication that lowers the amount of acid in your stomach. It’s available over the counter and with a prescription. Omeprazole can interact with medications that need acid to be absorbed. It can also affect certain medications that are processed through the liver. Omeprazole (Prilosec) is a proton pump inhibitor (PPI) that is used to reduce the amount of acid in your stomach and it can be bad for your kidneys. It can cause acute kidney injury and may also worsen the progression of chronic kidney disease (CKD). Use WebMD’s Drug Interaction Checker to identify potential interactions between medications, supplements, and foods. Reduce side effects and support safer treatment decisions. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases.